De Gautard G, Perrier A
Rev Med Suisse. 2014 Oct 15;10(446):1902, 1904-7.
Stroke is responsible for high morbidity and mortality. Antiplatelet agents are the cornerstone for secondary prevention of stroke and prescription of aspirin, clopidogrel or aspirin and dipyridamole are recommended based on strong evidence. Whether combining two antiplatelet agents would be more effective is still debated. Studies conducted in the early phase of stroke (from 24 hours to 3 months) show the superiority of dual antiplatelet the- rapy compared to aspirin alone. In contrast, long-term dual antiplatelet therapy is associated with an increased risk of intracranial hemorrhage and therefore deleterious. This article reviews current evidence and outlines future perspectives.
中风导致高发病率和死亡率。抗血小板药物是中风二级预防的基石，基于充分的证据，推荐使用阿司匹林、氯吡格雷或阿司匹林与双嘧达莫联合用药。联合使用两种抗血小板药物是否更有效仍存在争议。在中风早期（24小时至3个月）进行的研究表明，与单独使用阿司匹林相比，双重抗血小板治疗具有优越性。相比之下，长期双重抗血小板治疗会增加颅内出血的风险，因此是有害的。本文综述了当前的证据并概述了未来的前景。
