Mohr E, Fabbrini G, Williams J, Schlegel J, Cox C, Fedio P, Chase T N
Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Mov Disord. 1989;4(2):113-20. doi: 10.1002/mds.870040202.
Response fluctuations in motor function, complicating long-term dopaminomimetic therapy of Parkinson's disease, may extend to the cognitive realm. To evaluate the effect of levodopa treatment both on attention as well as acquisition and retrieval of memory tasks, parkinsonian patients were examined neuropsychologically both while medicated with levodopa/carbidopa ("on") and when the medication's antiparkinsonian effect had worn off ("off"). Significant cognitive differences emerged only on the delayed recall of complex verbal materials, where patients when "on" performed better compared with their "off" state. Comparison of change scores across states (administration or withholding of levodopa/carbidopa between acquisition and retrieval, "off" to "on" or "on" to "off"), revealed no substantial differences as a function of dopaminomimetic therapy. These results support the view that slight changes in cognition are associated with dopaminomimetic therapy of Parkinson's disease, but that these changes may be task-specific.
运动功能的反应波动使帕金森病的长期多巴胺模拟疗法变得复杂，这种波动可能会扩展到认知领域。为了评估左旋多巴治疗对注意力以及记忆任务的获取和检索的影响，对帕金森病患者在服用左旋多巴/卡比多巴（“开”）时和药物的抗帕金森病作用消退后（“关”）进行了神经心理学检查。仅在复杂言语材料的延迟回忆方面出现了显著的认知差异，患者在“开”状态下的表现比“关”状态时更好。跨状态（在获取和检索之间给予或停用左旋多巴/卡比多巴，“关”到“开”或“开”到“关”）变化分数的比较显示，作为多巴胺模拟疗法的函数没有实质性差异。这些结果支持这样一种观点，即认知的轻微变化与帕金森病的多巴胺模拟疗法有关，但这些变化可能是特定任务的。
