Mohr E, Juncos J, Cox C, Litvan I, Fedio P, Chase T N
Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland.
J Neurol Neurosurg Psychiatry. 1990 Jul;53(7):603-6. doi: 10.1136/jnnp.53.7.603.
To evaluate the profile and extent of cognitive deficits in Parkinson's disease, afflicted patients of exceptional professional distinction, who continue to function successfully in leadership positions, were compared neuropsychologically to neurologically normal individuals, matched for sex, age, education and professional standing. While patients showed relative preservation of verbal skills and higher executive function, they exhibited a significant reduction in episodic memory and visuospatial function. The observation of circumscribed impairment in this select group of Parkinsonian patients further implicates cognitive and memory deficits as consistent features of Parkinson's disease.
为评估帕金森病认知缺陷的特征及程度，将患有帕金森病且具有卓越专业成就、仍在领导岗位上成功履职的患者与在性别、年龄、教育程度和职业地位方面相匹配的神经学正常个体进行神经心理学比较。虽然患者的语言技能和高级执行功能相对保留，但他们的情景记忆和视觉空间功能显著下降。在这一特定帕金森病患者群体中观察到的局限性损害进一步表明，认知和记忆缺陷是帕金森病的一致特征。
