克罗恩病中的遗传易感性以及宿主遗传学与肠道微生物群的相互作用。
The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease.
作者信息
Jianzhong Hu
机构信息
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 14-70 Icahn Building, New York, NY 10029, USA.
出版信息
Clin Lab Med. 2014 Dec;34(4):763-70. doi: 10.1016/j.cll.2014.08.003. Epub 2014 Sep 15.
Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection. Recent human microbiome studies suggest that the gut microbiome composition is differentiated in carriers of many risk variants of major CD susceptibility genes. This interplay between host genetics and its associated gut microbiome may play an essential role in the pathogenesis of CD. The ongoing microbiome research is aimed to investigate the detailed host genetics-microbiome interacting mechanism.
广泛的基因研究已确定了140多个易患克罗恩病（CD）的基因座。已表明几个主要的CD易感基因在识别和清除细菌感染的免疫反应方面损害生物学功能。最近的人类微生物组研究表明，肠道微生物组组成在许多主要CD易感基因的风险变异携带者中存在差异。宿主遗传学与其相关的肠道微生物组之间的这种相互作用可能在CD的发病机制中起重要作用。正在进行的微生物组研究旨在研究宿主遗传学与微生物组相互作用的详细机制。
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