Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 2017 Sep;46(3):481-492. doi: 10.1016/j.gtc.2017.05.004. Epub 2017 Jul 19.
Individuals with a genetic predisposition to Crohn's disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn's disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn's disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in the development and management of Crohn's disease.
具有克罗恩病遗传易感性的个体对环境触发因素产生异常免疫反应。越来越多的人认识到胃肠道微生物群在克罗恩病的发展中起着重要作用。全球肠道微生物多样性减少和特定细菌改变与克罗恩病有关。测序技术和生物信息学的进步以及与宿主遗传学的相关性不断提高对微生物群落的结构和功能及其与宿主免疫系统相互作用的认识。本文总结了目前关于肠道微生物组及其在克罗恩病发展和管理中的作用的文献。
