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An improved retroviral vector for gene transfer into undifferentiated cells.

作者信息

Hawley R G, Sabourin L A, Hawley T S

机构信息

Department of Experimental Oncology, Ottawa Regional Cancer Centre, University of Ottawa, Ontario, Canada.

出版信息

Nucleic Acids Res. 1989 May 25;17(10):4001. doi: 10.1093/nar/17.10.4001.

DOI:10.1093/nar/17.10.4001
PMID:2543963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC317899/
Abstract
摘要

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Expression of introduced genetic sequences in hematopoietic cells following retroviral-mediated gene transfer.
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Interferon beta transduction of peripheral blood lymphocytes from HIV-infected donors increases Th1-type cytokine production and improves the proliferative response to recall antigens.来自HIV感染供体的外周血淋巴细胞经β干扰素转导后，可增加Th1型细胞因子的产生，并改善对回忆抗原的增殖反应。
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11595-600. doi: 10.1073/pnas.94.21.11595.
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A conditional self-inactivating retrovirus vector that uses a tetracycline-responsive expression system.一种使用四环素反应性表达系统的条件性自我失活逆转录病毒载体。
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Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta.在组成型表达干扰素β的转化细胞中，在逆转录之前的步骤阻断逆转录病毒感染。
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2689-93. doi: 10.1073/pnas.91.7.2689.

本文引用的文献

1
X linkage of phosphoglycerate kinase in the mouse.小鼠中磷酸甘油酸激酶的X连锁
Biochem Genet. 1974 Jan;11(1):41-7. doi: 10.1007/BF00486618.
2
Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region.莫洛尼鼠白血病病毒包装信号延伸至gag区域的证据。
J Virol. 1987 May;61(5):1639-46. doi: 10.1128/JVI.61.5.1639-1646.1987.
3
Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.小鼠磷酸甘油酸激酶-1基因的克隆、表达及其启动子的核苷酸序列
Gene. 1987;60(1):65-74. doi: 10.1016/0378-1119(87)90214-9.
4
Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo.用于在培养的小鼠胚胎细胞和体内造血细胞中表达基因的逆转录病毒载体的开发。
J Virol. 1988 Oct;62(10):3795-801. doi: 10.1128/JVI.62.10.3795-3801.1988.
5
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.缺陷逆转录病毒载体能有效地将外源基因转导至造血干细胞中。
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2406-10. doi: 10.1073/pnas.84.8.2406.
6
A safe packaging line for gene transfer: separating viral genes on two different plasmids.一种用于基因转移的安全包装生产线：将病毒基因分离到两个不同的质粒上。
J Virol. 1988 Apr;62(4):1120-4. doi: 10.1128/JVI.62.4.1120-1124.1988.
7
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.通过基因靶向在小鼠胚胎衍生干细胞中进行定点诱变。
Cell. 1987 Nov 6;51(3):503-12. doi: 10.1016/0092-8674(87)90646-5.