Rao G H, White J G
Department of Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis.
Thromb Res. 1989 Mar 1;53(5):427-34. doi: 10.1016/0049-3848(89)90197-7.
Exposure of platelets to phospholipase A2 selectively obliterates the aggregation response of human platelets to the action of epinephrine. This treatment does not impair the affinity of the ligand binding although it reduces the number of sites available on platelets. Reduction in the number of alpha receptors caused by phospholipase treatment in no way affected the epinephrine-induced restoration of sensitivity of refractory platelets to the action of agonists.
血小板暴露于磷脂酶A2会选择性地消除人类血小板对肾上腺素作用的聚集反应。这种处理不会损害配体结合的亲和力，尽管它会减少血小板上可用的位点数量。磷脂酶处理导致的α受体数量减少丝毫不会影响肾上腺素诱导的难治性血小板对激动剂作用的敏感性恢复。
