兔血小板α和β肾上腺素能受体数量的变化及血小板聚集

Changes in rabbit platelet alpha and beta adrenoceptor number and platelet aggregation.

作者信息

Hamilton C A, Deighton N M, Jones C R, Reid J L

出版信息

Eur J Pharmacol. 1986 Oct 14;130(1-2):145-9. doi: 10.1016/0014-2999(86)90195-0.

Abstract

Treatment with phenoxybenzamine caused a decrease in the number of alpha but not beta adrenoceptor ligand binding sites on platelets from male rabbits and thus a decrease in the ratio of alpha/beta adrenoceptor number. This was accompanied by decreased aggregation both in the presence and absence of propranolol. In contrast in female rabbits maturation and oestrogen treatment resulted in a decrease in both alpha and beta adrenoceptor ligand binding and no change in the alpha/beta adrenoceptor ratio or in the aggregatory response of the platelets to adrenaline in the absence of propranolol.

摘要

用酚苄明治疗导致雄性兔血小板上α-肾上腺素能受体配体结合位点数量减少，但β-肾上腺素能受体配体结合位点数量未减少，因此α/β-肾上腺素能受体数量之比降低。这伴随着在有和没有普萘洛尔存在的情况下血小板聚集的减少。相比之下，在雌性兔中，成熟和雌激素治疗导致α和β-肾上腺素能受体配体结合均减少，在没有普萘洛尔的情况下，α/β-肾上腺素能受体比例或血小板对肾上腺素的聚集反应没有变化。