Shevliagin V Ia, Snegireva A E, Shaposhnikova G M, Lapaeva I A, Petrukhin V G
Zh Mikrobiol Epidemiol Immunobiol. 1989 Apr(4):14-7.
The dose-dependent action of Shigella sonnei lipopolysaccharide (LPS) on the development of acute erythroleukocytosis, as well as Rauscher chronic myeloid and lymphoid leukosis, in BALB/c mice sensitive to Rauscher virus was shown. Bordetella pertussis LPS in the doses used in this investigation stimulated the development of both acute erythroleukosis and chronic myeloid and lymphoid leukosis in BALB/c mice infected with Rauscher virus. Lipid A isolated from B. pertussis LPS was found to produce a stimulating effect on the development of Rauscher leukosis in mice. After the treatment of B. pertussis LPS with polymyxin B blocking lipid A no stimulating effect of B. pertussis LPS on the development of Rauscher leukosis was observed. A suggestion is made that lipid A is the active principle contributing to the stimulation of the development of Rauscher leukosis in BALB/c mice.
已表明，宋内志贺氏菌脂多糖（LPS）对感染劳斯氏病毒敏感的BALB/c小鼠急性红白血病以及劳斯氏慢性髓性和淋巴细胞性白血病的发展具有剂量依赖性作用。本研究中使用的剂量的百日咳博德特氏菌LPS刺激感染劳斯氏病毒的BALB/c小鼠急性红白血病以及慢性髓性和淋巴细胞性白血病的发展。发现从百日咳博德特氏菌LPS中分离出的脂多糖A对小鼠劳斯氏白血病的发展产生刺激作用。用多粘菌素B阻断脂多糖A处理百日咳博德特氏菌LPS后，未观察到百日咳博德特氏菌LPS对劳斯氏白血病发展的刺激作用。有人提出，脂多糖A是促进BALB/c小鼠劳斯氏白血病发展的刺激作用的活性成分。
