Department of Nuclear Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Pediatr Neonatol. 2016 Dec;57(6):531-534. doi: 10.1016/j.pedneo.2014.04.010. Epub 2014 Oct 28.
Invasive fungal infections in children with acute lymphoblastic leukemia have been a major cause of mortality. Recent reports have described increasing incidence of invasive non-Aspergillus mold infections in patients with hematological malignancies. It is always challenging to treat invasive fungal infection and underlying hematological malignancies successfully. Here we report a girl with high-risk acute lymphoblastic leukemia who developed disseminated Cunninghamella bertholletiae infection during induction chemotherapy. This case illustrates the difficulties of diagnosis and treatment of invasive C. bertholletiae infection. It also highlights the necessity for physicians to keep high suspicion and awareness for this infrequent fungal infection.
儿童急性淋巴细胞白血病中的侵袭性真菌感染一直是导致死亡的主要原因。最近的报告描述了血液恶性肿瘤患者侵袭性非曲霉霉菌感染的发生率不断增加。成功治疗侵袭性真菌感染和潜在血液恶性肿瘤一直是一个挑战。在这里，我们报告了一例高危急性淋巴细胞白血病患儿，在诱导化疗期间发生播散性贝氏梭菌感染。本病例说明了诊断和治疗侵袭性 C. bertholletiae 感染的困难。它还强调了医生保持对这种罕见真菌感染的高度怀疑和认识的必要性。
