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正常体重、肥胖和病态肥胖患者输尿管软镜治疗肾结石的对比研究

Comparative study of the treatment of renal stones with flexible ureterorenoscopy in normal weight, obese, and morbidly obese patients.

作者信息

Doizi Steeve, Letendre Julien, Bonneau Claire, Gil Diez de Medina Sixtina, Traxer Olivier

机构信息

Department of Urology, Tenon Hospital, Paris, France; Pierre and Marie Curie University, Tenon Hospital, Paris, France.

Department of Urology, Tenon Hospital, Paris, France.

出版信息

Urology. 2015 Jan;85(1):38-44. doi: 10.1016/j.urology.2014.08.028. Epub 2014 Oct 29.

Abstract

OBJECTIVE

To compare the efficacy and the safety of flexible ureterorenoscopy (f-URS) in the treatment of kidney stones according to the body mass index (BMI), which seems to be less influenced by weight compared with shock wave lithotripsy and percutaneous nephrolithotomy.

METHODS

We conducted a retrospective monocentric study in patients with a known BMI who underwent an f-URS for kidney stones between 2006 and 2008. Success rates in the obese patients (OP) group (BMI ≥30 kg/m(2)) were compared with success rates in the normal weight patients (NWP) control group (BMI <25 kg/m(2)). Patients with a BMI ≥40 kg/m(2) were defined as morbidly obese patients (MOP), a subgroup of the OP group. The success was defined as a stone-free status (no or ≤2 mm residual stone) at the time of control, 3 months after the procedure assessed by kidneys-ureters-bladder radiography coupled with ultrasound (only in NWP with radiopaque stones), or computed tomography-scan.

RESULTS

A total of 327 procedures were performed, including 97 f-URS in 87 OP (including 14 procedures in 13 MOP) and 230 procedures for 188 NWP. The overall success rate was 67.4% and 68% in the NWP and OP, respectively; P = .91 (71.4% in the MOP subgroup). Success rates decreased with an increasing stone size without any differences between the groups. Regardless of location and stone size (<10, 10-20, >20 mm), there was no statistical difference in the success rate. Postoperative morbidity was similar in both groups and occurred in 2.44% of cases.

CONCLUSION

f-URS for kidney stones resulted in similar outcomes in NWP and OP, and even MOP, regardless of stone size and location and with equivalent morbidity.

摘要

目的

根据体重指数(BMI)比较软性输尿管肾镜检查(f-URS)治疗肾结石的疗效和安全性,与冲击波碎石术和经皮肾镜取石术相比,f-URS似乎受体重影响较小。

方法

我们对2006年至2008年间因肾结石接受f-URS且已知BMI的患者进行了一项回顾性单中心研究。将肥胖患者(OP)组(BMI≥30kg/m²)的成功率与正常体重患者(NWP)对照组(BMI<25kg/m²)的成功率进行比较。BMI≥40kg/m²的患者被定义为病态肥胖患者(MOP),是OP组的一个亚组。成功定义为在术后3个月复查时结石清除状态(无残留结石或残留结石≤2mm),通过肾脏-输尿管-膀胱造影联合超声检查(仅适用于有不透X线结石的NWP)或计算机断层扫描评估。

结果

共进行了327例手术,其中87例OP患者接受了97次f-URS(包括13例MOP患者的14次手术),188例NWP患者接受了230次手术。NWP组和OP组的总体成功率分别为67.4%和68%;P = 0.91(MOP亚组为71.4%)。成功率随结石大小增加而降低,两组间无差异。无论结石位置和大小(<10、10 - 20、>20mm)如何,成功率均无统计学差异。两组术后发病率相似,为2.44%。

结论

无论结石大小、位置如何,f-URS治疗肾结石在NWP、OP甚至MOP患者中都能取得相似的结果,且发病率相当。

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