Hautmann Richard E, Abol-Enein Hassan, Lee Cheryl T, Mansson Wiking, Mills Robert D, Penson David F, Skinner Eila C, Studer Urs E, Thueroff Joachim W, Volkmer Bjoern G
Department of Urology, University of Ulm, Ulm, Germany.
Department of Urology, Mansoura University, Mansoura, Egypt.
Urology. 2015 Jan;85(1):233-8. doi: 10.1016/j.urology.2014.06.075. Epub 2014 Nov 8.
To determine the rates of the available urinary diversion options for patients treated with radical cystectomy for bladder cancer in different settings (pioneering institutions, leading urologic oncology centers, and population based).
Population-based data from the literature included all patients (n = 7608) treated in Sweden during the period 1964-2008, from Germany (n = 14,200) for the years 2008 and 2011, US patients (identified from National Inpatient Sample during 1998-2005, 35,370 patients and 2001-2008, 55,187 patients), and from Medicare (n = 22,600) for the years 1992, 1995, 1998, and 2001. After the International Consultation on Urologic Diseases-European Association of Urology International Consultation on Bladder Cancer 2012, the urinary diversion committee members disclosed data from their home institutions (n = 15,867), including the pioneering institutions and the leading urologic oncology centers. They are the coauthors of this report.
The receipt of continent urinary diversion in Sweden and the United States is <15%, whereas in the German high-volume setting, 30% of patients receive a neobladder. At leading urologic oncology centers, this rate is also 30%. At pioneering institutions up to 75% of patients receive an orthotopic reconstruction. Anal diversion is <1%. Continent cutaneous diversion is the second choice.
Enormous variations in urinary diversion exist for >2 decades. Increased attention in expanding the use of continent reconstruction may help to reduce these disparities for patients undergoing radical cystectomy for bladder cancer. Continent reconstruction should not be the exclusive domain of cystectomy centers. Efforts to increase rates of this complex reconstruction must concentrate on better definition of the quality-of-life impact, technique dissemination, and the centralization of radical cystectomy.
确定在不同环境下(开拓性机构、领先的泌尿肿瘤中心以及基于人群)接受膀胱癌根治性膀胱切除术的患者中,可用尿流改道方式的比例。
来自文献的基于人群的数据包括1964年至2008年期间在瑞典接受治疗的所有患者(n = 7608)、2008年和2011年来自德国的患者(n = 14200)、美国患者(从1998年至2005年的国家住院样本中识别出35370例患者以及2001年至2008年的55187例患者),以及1992年、1995年、1998年和2001年来自医疗保险的数据(n = 22600)。在2012年国际泌尿疾病咨询 - 欧洲泌尿外科学会膀胱癌国际咨询会后,尿流改道委员会成员披露了他们所在机构(n = 15867)的数据,包括开拓性机构和领先的泌尿肿瘤中心。他们是本报告的共同作者。
在瑞典和美国,可控性尿流改道的接受率低于15%,而在德国大量病例的环境中,30%的患者接受新膀胱。在领先的泌尿肿瘤中心,这一比例也是30%。在开拓性机构,高达75%的患者接受原位重建。肛门改道的比例低于1%。可控性皮肤造口术是第二选择。
二十多年来尿流改道方式存在巨大差异。加大对扩大可控性重建使用的关注,可能有助于减少接受膀胱癌根治性膀胱切除术患者的这些差异。可控性重建不应是膀胱切除术中心的专属领域。提高这种复杂重建比例的努力必须集中在更好地界定对生活质量的影响、技术传播以及膀胱癌根治术的集中化。