利什曼病犬的血清高密度脂蛋白（HDL）浓度。
Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs.
作者信息
Ibba Fabrizio, Rossi Gabriele, Meazzi Sara, Giordano Alessia, Paltrinieri Saverio
机构信息
Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy; Veterinary Clinic Poggio di Pini, Capoterra (CA), Italy.
Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy.
出版信息
Res Vet Sci. 2015 Feb;98:89-91. doi: 10.1016/j.rvsc.2014.11.011. Epub 2014 Nov 18.
In order to assess whether the concentration of high density lipoproteins (HDLs) changes in leishmaniotic dogs before and after treatment, HDL cholesterol (HDL-Chol and HDL%), C reactive protein (CRP) and activity of the antioxidant enzyme paraoxonase (PON-1) were measured in sera from 10 controls and 10 leishmaniotic dogs. Seven of these latter were sampled also 3, 7, 14, 21 and 28 days after treatment with antimonials and allopurinol. HDL-chol, and PON-1 were low in leishmaniotic dogs at admission and increased after treatment. HDL-chol and HDL% correlated positively with PON-1 and negatively with CRP suggesting that HDLs decrease through an oxidative mechanism. Therefore, HDLs may be used to monitor the magnitude of oxidation associated with inflammation in leishmaniotic dogs.
为了评估利什曼病犬治疗前后高密度脂蛋白（HDL）浓度是否发生变化，对10只对照犬和10只利什曼病犬的血清进行了高密度脂蛋白胆固醇（HDL-Chol和HDL%）、C反应蛋白（CRP）以及抗氧化酶对氧磷酶（PON-1）活性的检测。其中7只利什曼病犬在接受锑剂和别嘌呤醇治疗后的第3、7、14、21和28天也进行了采样。利什曼病犬入院时HDL-chol和PON-1水平较低，治疗后升高。HDL-chol和HDL%与PON-1呈正相关，与CRP呈负相关，提示HDL通过氧化机制降低。因此，HDL可用于监测利什曼病犬炎症相关氧化程度。
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