Joshi V V, Beckwith J B
Department of Pathology and Pediatrics, Children's Hospital of New Jersey, Newark.
Cancer. 1989 Jul 15;64(2):466-79. doi: 10.1002/1097-0142(19890715)64:2<466::aid-cncr2820640221>3.0.co;2-v.
The entities commonly known as multi-locular cyst of the kidney (MLC) and cystic partially differentiated nephroblastoma (CPDN) were reviewed, based on material in the National Wilms' Tumor Study Pathology Center. The authors recommend several modifications of existing terminology and definitional criteria for these lesions. Because MLC probably represents a neoplastic lesion, the designation "cystic nephroma" (CN) is preferred. This term should be used only for predominantly cystic tumors composed entirely of differentiated tissues, without blastema or other embryonal elements. The designation CPDN should be applied to predominantly cystic lesions, lacking nodular solid regions, in which blastemal or other embryonal cells are present in the septa of the cysts. Solid Wilms' tumor with multifocal cystic change should be distinguished from CPDN. Five cases of CN and 18 cases of CPDN were reviewed. No CN, for which follow-up data was available, showed aggressive behavior. Only one case of CPDN underwent local recurrence, and there were no metastases. In general, nephrectomy alone appears to be adequate therapy for CPDN, but regular monitoring by noninvasive techniques would seem advisable.
基于国家威尔姆斯瘤研究病理中心的资料，对通常被称为肾多房囊肿（MLC）和囊性部分分化型肾母细胞瘤（CPDN）的实体进行了回顾。作者建议对这些病变的现有术语和定义标准进行若干修改。由于MLC可能代表一种肿瘤性病变，因此首选“囊性肾瘤”（CN）这一名称。该术语仅应用于完全由分化组织组成、无胚芽或其他胚胎成分的主要为囊性的肿瘤。CPDN这一名称应应用于主要为囊性、缺乏结节状实性区域、囊肿间隔中存在胚芽或其他胚胎细胞的病变。实性威尔姆斯瘤伴多灶性囊性改变应与CPDN相鉴别。回顾了5例CN和18例CPDN。有随访数据的CN病例均未表现出侵袭性。CPDN仅1例出现局部复发，无转移。一般来说，单纯肾切除术似乎是CPDN的充分治疗方法，但采用非侵入性技术进行定期监测似乎是可取的。
