Zhou Xiaodong, Zhang Wenyi, Liu Xiaoli, Zhang Wu, Li Yiming
Center for Dental Research, Loma Linda University School of Dentistry, Loma Linda, CA, United States.
Department of Medicine, Loma Linda University Medical Center, Loma Linda, CA, United States.
Arch Oral Biol. 2015 Apr;60(4):667-74. doi: 10.1016/j.archoralbio.2014.11.008. Epub 2014 Nov 20.
Diabetes mellitus and periodontitis are both common, chronic diseases. It is generally accepted that the inter-relationship between diabetes mellitus and periodontitis is a two-way relationship, i.e. the presence of one condition tends to increases the risk and severity of the other, and vice versa. Mechanisms for this two-way relationship are largely unknown. Hyperlipidemia is a group of disorders characterized by an excess of lipids in the bloodstream. Hyperlipidemia increases the risk of diabetes and peridontitis. On the other hand, diabetes and periodontitis could result in hyperlipidemia. The purposes of this review were: (1) examine the two-way relationship between diabetes mellitus and periodontitis; (2) discuss the potential synergistic interactions of hyperlipidemia to both diabetes mellitus and periodontitis; and (3) explore the mechanisms through which hyperlipidemia affects the development of both diseases. The effects of hyperlipidemia on insulin secretion and pro-inflammatory cytokines production (TNF-α, IL-1β) play an important role on the pathogenesis of diabetes and periodontitis. A model is proposed suggesting the important role of hyperlipidemia in the two-way relationship between diabetes and periodontitis. As our understanding of the inter-relationship expands between hyperlipidemia, diabetes, and periodontitis, therapeutic strategies aimed at limiting hyperlipidemia should be advocated for the clinical management of diabetes and periodontitis.
糖尿病和牙周炎都是常见的慢性疾病。人们普遍认为，糖尿病与牙周炎之间的相互关系是一种双向关系，即一种疾病的存在往往会增加另一种疾病的风险和严重程度，反之亦然。这种双向关系的机制在很大程度上尚不清楚。高脂血症是一组以血液中脂质过多为特征的病症。高脂血症会增加患糖尿病和牙周炎的风险。另一方面，糖尿病和牙周炎可能导致高脂血症。本综述的目的是：（1）研究糖尿病与牙周炎之间的双向关系；（2）讨论高脂血症对糖尿病和牙周炎的潜在协同相互作用；（3）探索高脂血症影响这两种疾病发展的机制。高脂血症对胰岛素分泌和促炎细胞因子产生（TNF-α、IL-1β）的影响在糖尿病和牙周炎的发病机制中起重要作用。本文提出了一个模型，表明高脂血症在糖尿病和牙周炎的双向关系中具有重要作用。随着我们对高脂血症、糖尿病和牙周炎之间相互关系的理解不断扩展，应提倡针对限制高脂血症的治疗策略用于糖尿病和牙周炎的临床管理。
