He Fangzhou, Liu Junshi, Huang Yuanding, Chen Lan, Rizi Ehsan Parvaresh, Zhang Ke, Ke Lijing, Loh Tze Ping, Niu Meng, Peng Weng Kung
Songshan Lake Materials Laboratory, Dongguan, China.
Dongguan Institute of Technology, Dongguan, China.
NPJ Sci Food. 2024 Jun 27;8(1):41. doi: 10.1038/s41538-024-00282-x.
Diabetes mellitus affected more than 500 million of people globally, with an annual mortality of 1.5 million directly attributable to diabetic complications. Oxidative stress, in particularly in post-prandial state, plays a vital role in the pathogenesis of the diabetic complications. However, oxidative status marker is generally poorly characterized and their mechanisms of action are not well understood. In this work, we proposed a new framework for deep characterization of oxidative stress in erythrocytes (and in urine) using home-built micro-scale NMR system. The dynamic of post-prandial oxidative status (against a wide variety of nutritional load) in individual was assessed based on the proposed oxidative status of the red blood cells, with respect to the traditional risk-factors such as urinary isoprostane, reveals new insights into our understanding of diabetes. This new method can be potentially important in drafting guidelines for sub-stratification of diabetes mellitus for clinical care and management.
全球有超过5亿人受糖尿病影响，每年有150万人直接死于糖尿病并发症。氧化应激，尤其是在餐后状态下，在糖尿病并发症的发病机制中起着至关重要的作用。然而，氧化状态标志物通常特征不明显，其作用机制也尚未完全了解。在这项工作中，我们提出了一个新的框架，用于使用自制的微型核磁共振系统对红细胞（和尿液）中的氧化应激进行深度表征。基于所提出的红细胞氧化状态，评估个体餐后氧化状态（针对多种营养负荷）的动态变化，相对于传统风险因素如尿异前列腺素，这为我们对糖尿病的理解提供了新的见解。这种新方法在制定糖尿病临床护理和管理的亚分层指南方面可能具有重要意义。
