Mou Wenjun, Xu Yingxi, Ye Yujie, Chen Si, Li Xuefei, Gong Kangzi, Liu Yanhua, Chen Yanan, Li Xiru, Tian Yaping, Xiang Rong, Li Na
School of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China; Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China; Department of Biochemistry, Chinese PLA General Hospital, Beijing 100853, China.
School of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Cancer Lett. 2015 Mar 28;358(2):115-123. doi: 10.1016/j.canlet.2014.11.004. Epub 2014 Nov 11.
Transcriptional factor Sox2 promotes tumor metastasis; however its regulatory effect on tumor-associated macrophages (TAMs, M2 phenotype) has not been defined. This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer and showed that Sox2 in breast cancer cells promotes recruitment of TAMs with altered expression of multiple chemokines, including MIP-1α, ICAM-1 etc. and activation of Stat3 and NF-κB signalings. In addition, TAMs rescued the compromised lung metastasis induced by Sox2 silencing in breast cancer cells. Together, this study documented that Sox2 plays an important role in recruiting TAMs and promotes tumor metastasis in a TAMs dependent manner.
转录因子Sox2促进肿瘤转移；然而，其对肿瘤相关巨噬细胞（TAMs，M2表型）的调节作用尚未明确。本研究揭示了TAMs标志物-CD163与SOX2在人类乳腺癌中的共表达，并表明乳腺癌细胞中的Sox2促进了TAMs的募集，同时多种趋化因子（包括MIP-1α、ICAM-1等）的表达发生改变，以及Stat3和NF-κB信号通路的激活。此外，TAMs挽救了乳腺癌细胞中因Sox2沉默而受损的肺转移。总之，本研究证明Sox2在募集TAMs中起重要作用，并以TAMs依赖的方式促进肿瘤转移。
