Li Jinke, Xu Yawen, Han Yunying, Yang Aifu, Qian Miaoshan, Wang Bo
Department of General Surgery, Longnan First People's Hospital, Longnan, China.
Medicine (Baltimore). 2025 Jan 31;104(5):e41393. doi: 10.1097/MD.0000000000041393.
Cancer immune evasion is one of the important mechanisms for cancer development, which is essential to developing novel immunotherapeutic strategies. The SOX (SRY-related HMG-box) family of transcription factors plays a crucial role in normal physiology as well as in a variety of human diseases especially cancer. It has been shown that SOX is involved in cancer immune evasion processes. This mini-review aimed to summarize how SOX family members induce cancer immune evasion by regulating antigen presentation, shaping the tumor immunosuppressive milieu, and controlling regulatory immune checkpoint inhibitors like programmed death ligand 1. Thorough exploration of SOX family will help uncover the mechanism of cancer immune evasion, and provide new ideas and targets for the development of immunotherapy strategies.
癌症免疫逃逸是癌症发展的重要机制之一，这对于开发新型免疫治疗策略至关重要。SOX（SRY相关高迁移率族盒）转录因子家族在正常生理过程以及多种人类疾病尤其是癌症中发挥着关键作用。研究表明，SOX参与癌症免疫逃逸过程。本综述旨在总结SOX家族成员如何通过调节抗原呈递、塑造肿瘤免疫抑制微环境以及控制程序性死亡配体1等免疫检查点抑制剂来诱导癌症免疫逃逸。深入探究SOX家族将有助于揭示癌症免疫逃逸的机制，并为免疫治疗策略的开发提供新思路和靶点。
