Li Chunhui, Guan Guangying, Ling Yuting, Hsu Ying-Ting, Song Shaozhen, Huang Jeffrey T-J, Lang Stephen, Wang Ruikang K, Huang Zhihong, Nabi Ghulam
Academic Section of Urology, Division of Imaging Technology, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom.
School of Engineering, Physics and Mathematics, University of Dundee, Dundee, Scotland DD1 4HN, United Kingdom; Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, United States.
Cancer Lett. 2015 Feb 1;357(1):121-128. doi: 10.1016/j.canlet.2014.11.021. Epub 2014 Nov 21.
We present first quantitative three-dimensional (3D) data sets recorded using optical coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 transrectal ultrasound guided prostate biopsy specimens from 10 men suspected with prostate cancer were imaged using OCE. 3D quantitative mechanical assessment of biopsy specimens obtained in kilopascals (kPa) at an interval of 40 µm was compared with histopathology. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE in comparison to histopathology. The results show OCE imaging could reliably differentiate between benign prostate tissue, acinar atypical hyperplasia, prostatic intraepithelial neoplasia and malignant PCa. The sensitivity and specificity of OCE for the detection of prostate cancer was 0.98 and 0.91 with AUC > 0.99. Quantitative 3D OCE based on the assessment of mechanical properties of tissues can reliably differentiate prostate tissue specimen in an ex-vivo setting. This is a promising imaging modality for characterising different grades of cancers.
我们展示了首次使用光学相干弹性成像（OCE）记录的用于前列腺癌（PCa）诊断和检测的定量三维（3D）数据集。对10名疑似前列腺癌男性的120份经直肠超声引导的前列腺活检标本进行了OCE成像。将以千帕（kPa）为单位、间隔40 µm获得的活检标本的三维定量力学评估结果与组织病理学结果进行了比较。计算了与组织病理学相比OCE的敏感性、特异性以及阳性和阴性预测值。结果表明，OCE成像能够可靠地区分良性前列腺组织、腺泡非典型增生、前列腺上皮内瘤变和恶性PCa。OCE检测前列腺癌的敏感性和特异性分别为0.98和0.91，曲线下面积（AUC）>0.99。基于组织力学特性评估的定量三维OCE能够在体外可靠地区分前列腺组织标本。这是一种用于表征不同癌症分级的有前景的成像方式。
