Institute of Health and Biomedical Innovation, Queensland University of Technology, 2 George St., Brisbane 4000, QLD, Australia.
Institute of Health and Biomedical Innovation, Queensland University of Technology, 2 George St., Brisbane 4000, QLD, Australia.
J Anxiety Disord. 2014 Dec;28(8):873-83. doi: 10.1016/j.janxdis.2014.09.014. Epub 2014 Oct 5.
Posttraumatic stress disorder (PTSD) is a complex syndrome that occurs following exposure to a potentially life threatening traumatic event. This review summarises the literature on the genetics of PTSD including gene-environment interactions (GxE), epigenetics and genetics of treatment response. Numerous genes have been shown to be associated with PTSD using candidate gene approaches. Genome-wide association studies have been limited due to the large sample size required to reach statistical power. Studies have shown that GxE interactions are important for PTSD susceptibility. Epigenetics plays an important role in PTSD susceptibility and some of the most promising studies show stress and child abuse trigger epigenetic changes. Much of the molecular genetics of PTSD remains to be elucidated. However, it is clear that identifying genetic markers and environmental triggers has the potential to advance early PTSD diagnosis and therapeutic interventions and ultimately ease the personal and financial burden of this debilitating disorder.
创伤后应激障碍（PTSD）是一种复杂的综合征，发生在经历潜在威胁生命的创伤性事件之后。这篇综述总结了 PTSD 的遗传学研究，包括基因-环境相互作用（GxE）、表观遗传学和治疗反应的遗传学。使用候选基因方法已经发现许多基因与 PTSD 相关。全基因组关联研究由于需要大样本量才能达到统计学效力而受到限制。研究表明，GxE 相互作用对 PTSD 的易感性很重要。表观遗传学在 PTSD 的易感性中起着重要作用，一些最有前途的研究表明，压力和儿童虐待会引发表观遗传变化。 PTSD 的大部分分子遗传学仍有待阐明。然而，很明显，确定遗传标记和环境触发因素有可能促进 PTSD 的早期诊断和治疗干预，并最终减轻这种使人衰弱的疾病给个人和经济带来的负担。
