Department of Psychiatry, University of Würzburg, Würzburg, Germany.
Psychiatr Danub. 2012 Sep;24(3):267-73.
Clinical genetic studies propose a moderate genetic contribution to the pathogenesis of PTSD with a heritability of about 30-35%. The present brief review will give an overview of molecular genetic research in PTSD yielding support for specific vulnerability genes. Additionally, evidence for gene-environment (GxE) interactions between susceptibility genes of PTSD and traumatic experiences will be reported. Recent studies suggest a pivotal role of epigenetic mechanisms such as DNA methylation in mediating the impact of trauma in the pathogenesis of PTSD. Future approaches to further unravel the genetic underpinnings of PTSD might comprise genome-wide association studies (GWAS), the investigation of the genetic influence on intermediate phenotypes of PTSD (e.g., imaging genetics) as well as pharmaco- and psychotherapy-genetic studies. Genetic research in PTSD will be discussed with respect to its potential benefit regarding innovative and individually tailored therapeutic approaches in PTSD.
临床遗传学研究提出 PTSD 的发病机制中存在中度遗传贡献，遗传率约为 30-35%。本简要综述将概述 PTSD 的分子遗传学研究，为特定易感性基因提供支持。此外，还将报告 PTSD 易感性基因与创伤经历之间的基因-环境（GxE）相互作用的证据。最近的研究表明，表观遗传机制（如 DNA 甲基化）在介导创伤对 PTSD 发病机制的影响中起着关键作用。进一步揭示 PTSD 遗传基础的未来方法可能包括全基因组关联研究（GWAS）、对 PTSD 中间表型（如影像学遗传学）的遗传影响的研究以及药物和心理治疗遗传学研究。本文将讨论 PTSD 的遗传研究，以及其在 PTSD 的创新和个体化治疗方法方面的潜在益处。
