Department of Urology, University of California, San Francisco, CA, USA; King Abdul Aziz University, Jeddah, Saudi Arabia.
Department of Urology, University of California, San Francisco, CA, USA.
Adv Drug Deliv Rev. 2015 Mar;82-83:137-44. doi: 10.1016/j.addr.2014.11.012. Epub 2014 Nov 14.
Erectile Dysfunction (ED) is a common disease that typically affects older men. While oral type-5 phosphodieserase inhibitors (PDE5Is) represent a successful first-line therapy, many patients do not respond to this treatment leading researchers to look for alternative treatment modalities. Stem cell (SC) therapy is a promising new frontier for the treatment of those patients and many studies demonstrated its therapeutic effects. In this article, using a Medline database search of all relevant articles, we present a summary of the scientific principles behind SCs and their use for treatment of ED. We discuss specifically the different types of SCs used in ED, the methods of delivery tested, and the methods attempted to enhance SC therapy effect. In addition, we review the current preclinical literature on SC therapy for ED and present a summary of its findings in addition to the single clinical trial published.
勃起功能障碍（ED）是一种常见的疾病，通常影响老年男性。虽然口服 5 型磷酸二酯酶抑制剂（PDE5Is）是一种成功的一线治疗方法，但许多患者对这种治疗方法没有反应，这促使研究人员寻找替代治疗方法。干细胞（SC）治疗是治疗这些患者的一个有前途的新领域，许多研究已经证明了它的治疗效果。在本文中，我们通过对所有相关文章的 Medline 数据库搜索，总结了 SC 治疗 ED 的科学原理及其应用。我们特别讨论了 ED 中使用的不同类型的 SC、测试的输送方法以及试图增强 SC 治疗效果的方法。此外，我们还回顾了 SC 治疗 ED 的当前临床前文献，并总结了除已发表的一项单一临床试验外的研究结果。
