Compté Nathalie, Bailly Benjamin, De Breucker Sandra, Goriely Stanislas, Pepersack Thierry
Service de gériatrie, Hôpital Soignies, Rue de la station 103, 7090 Braine-le-comte, Belgium.
Service d'hématologie, Hôpital Erasme, 808 route de Lennik, 1070 Bruxelles, Belgium.
Exp Gerontol. 2015 Jan;61:105-12. doi: 10.1016/j.exger.2014.11.016. Epub 2014 Nov 22.
BACKGROUND/OBJECTIVES: Geriatric patients are highly susceptible to infections. While reduced lymphocyte count has been associated with age, other studies found no change in WBC counts with age. Increased circulating white blood cell (WBC) count has been associated with cardiovascular (CV) diseases and frailty but there are discrepancies. Frailty, geriatric conditions, cardiovascular diseases and WBC count have also been associated with low grade inflammation. Association between geriatric conditions and WBC has been scarcely studied. The aim of the study is to assess the association between WBC and geriatric conditions, CV diseases, and seric IL-6 levels.
DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: We recruited 100 subjects in the general population and hospitalized for chronic medical conditions (age, 23-96years). We collected information on clinical status (medical history, comorbidities, treatments and geriatric syndromes), biological parameters (hematological tests, cytomegalovirus serology) and cytokine production (basal IL-6). Using stepwise backward multivariate analyses, we defined which set of clinical and biological variables could be predictive of increased total and differential WBC counts.
We found that low-grade inflammation is independently associated with total WBC, monocyte and neutrophil counts, but not geriatric conditions. CV diseases were the only significant associated factor for high monocyte count.
In this study, we observed that differential and total WBC counts do not seem to be associated with geriatric conditions but with CV diseases, low-grade inflammation and telomere length.
背景/目的：老年患者极易感染。虽然淋巴细胞计数降低与年龄有关，但其他研究发现白细胞计数不会随年龄变化。循环白细胞（WBC）计数增加与心血管（CV）疾病和虚弱有关，但存在差异。虚弱、老年疾病、心血管疾病和白细胞计数也与低度炎症有关。老年疾病与白细胞之间的关联鲜有研究。本研究的目的是评估白细胞与老年疾病、心血管疾病及血清白细胞介素-6水平之间的关联。
设计、地点、参与者、测量方法：我们招募了100名普通人群中因慢性疾病住院的受试者（年龄23 - 96岁）。我们收集了临床状况（病史、合并症、治疗和老年综合征）、生物学参数（血液学检查、巨细胞病毒血清学）和细胞因子产生（基础白细胞介素-6）的信息。使用逐步向后多变量分析，我们确定了哪一组临床和生物学变量可预测白细胞总数和分类计数增加。
我们发现低度炎症与白细胞总数、单核细胞和中性粒细胞计数独立相关，但与老年疾病无关。心血管疾病是单核细胞计数高的唯一显著相关因素。
在本研究中，我们观察到白细胞分类计数和总数似乎与老年疾病无关，而是与心血管疾病、低度炎症和端粒长度有关。
