Daley Tom, Dunn Genevieve, Darling Mark R
Professor, Division of Oral Pathology, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Intern, Dental Department, London Health Sciences Center, London, Ontario, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):92-100. doi: 10.1016/j.oooo.2014.09.018. Epub 2014 Sep 28.
To investigate central lesions of the jaws dominated by foamy macrophages (foam cells), which are interpreted to be "central xanthomas of the jaws" and to differentiate this condition from reported cases of jaw nonossifying fibroma/fibrous cortical defect and benign fibrous histiocytoma of bone.
The study is a literature review and a retrospective analysis of clinical, radiographic, microscopic, and immunohistochemical features of five new cases of this condition.
The lesion has a predilection for the mandible in adults of variable ages, with the potential to become very large and destructive; however, it has a very low recurrence rate, if any, following surgical curettage.
We suggest that the "central xanthoma of the jaws" be considered a unique, although rare, clinicopathologic entity. It is unclear whether this lesion is a benign neoplastic process or a persistent reactive process.
研究以泡沫状巨噬细胞（泡沫细胞）为主的颌骨中心性病变，该病变被解释为“颌骨中心性黄瘤”，并将其与已报道的颌骨非骨化性纤维瘤/纤维皮质缺损及骨良性纤维组织细胞瘤病例相鉴别。
本研究为文献综述，并对5例该疾病新病例的临床、影像学、显微镜及免疫组化特征进行回顾性分析。
该病变好发于各年龄段成人的下颌骨，有可能变得非常大且具有破坏性；然而，手术刮除后复发率极低，甚至无复发。
我们认为“颌骨中心性黄瘤”是一种独特的临床病理实体，尽管罕见。尚不清楚该病变是良性肿瘤性过程还是持续性反应性过程。
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