School of Dentistry, Universidade de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Dentomaxillofac Radiol. 2011 Sep;40(6):393-6. doi: 10.1259/dmfr/51850495.
Bone xanthomas are rare and are usually are associated with endocrine or metabolic diseases, mainly lipid disorders. In the absence of systemic diseases, the lesion is called a primary xanthoma. Primary mandibular xanthomas are extremely rare. The aim of this report is to describe the clinical and radiographic findings of a primary mandibular xanthoma, discussing the epidemiological features, pathogenesis and differential diagnosis. A 25-year-old man was referred for evaluation of a left mandibular lesion detected in a routine radiographic exam. Radiographically, there was a diffuse, unilocular and radiolucent lesion, with irregular margins located adjacent to the surface from the distal root of the left mandibular third molar. The lesion was excised under local anaesthesia. Microscopically, there were several cells with a foamy and granular cytoplasm and central small, round nuclei, similar to xanthomatous macrophages. No lipid disorders were diagnosed. According to these features, the diagnosis of primary mandibular xanthoma was established. In conclusion, xanthomas of the jaws are rare and all seem to be primary and occur exclusively in the mandible.
骨黄色瘤罕见，通常与内分泌或代谢疾病相关，主要为脂代谢紊乱。在无系统性疾病的情况下，病变被称为原发性黄色瘤。下颌骨原发性黄色瘤极为罕见。本报告旨在描述 1 例原发性下颌骨黄色瘤的临床和影像学表现，讨论其流行病学特征、发病机制和鉴别诊断。1 名 25 岁男性因常规影像学检查发现左侧下颌骨病变而就诊。影像学表现为边界不规则的弥散性、单房性、透亮性病变，位于左侧下颌第三磨牙远中根表面附近。在局部麻醉下切除病变。镜下可见，多个细胞的胞质呈泡沫状和颗粒状，中央有小而圆的核，类似于黄色瘤样巨噬细胞。未诊断出脂代谢紊乱。根据这些特征，诊断为原发性下颌骨黄色瘤。总之，颌骨黄色瘤罕见，似乎均为原发性，且仅发生于下颌骨。
