在宫颈癌细胞系中扩增的整合型人乳头瘤病毒16型基因组的结构与表达
Structure and expression of an integrated human papillomavirus type 16 genome amplified in a cervical carcinoma cell line.
作者信息
Shirasawa H, Tomita Y, Fuse A, Yamamoto T, Tanzawa H, Sekiya S, Takamizawa H, Simizu B
机构信息
Department of Microbiology, School of Medicine, Chiba University, Japan.
出版信息
J Gen Virol. 1989 Jul;70 ( Pt 7):1913-9. doi: 10.1099/0022-1317-70-7-1913.
PMID:2544671
Abstract
A cellular sequence containing the integrated human papillomavirus type 16 genome in a cervical carcinoma cell line QG-U was cloned and analysed. The transcriptionally active viral genome disrupted at the E2 and L2 open reading frames was amplified with its flanking sequences.
摘要
对宫颈癌细胞系QG-U中包含整合的人乳头瘤病毒16型基因组的细胞序列进行了克隆和分析。在E2和L2开放阅读框处中断的转录活性病毒基因组及其侧翼序列被扩增。
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