Ohgushi H, Goldberg V M, Caplan A I
Department of Orthopaedics, Nara Medical University, Kashihara City, Japan.
J Orthop Res. 1989;7(4):568-78. doi: 10.1002/jor.1100070415.
When untreated porous calcium phosphate ceramics were transplanted into subcutaneous (s.c.) or intramuscular (i.m.) sites, fibrovascular tissue grew in the pore region without evidence of bone formation. However, when these same ceramics were combined with syngeneic marrow cells, osteogenesis was observed inside the pore region of the implanted ceramic. The osteogenesis began on the surface of the pore region at approximately 3 weeks postimplantation by a process of intramembranous bone formation, with the de novo bone tissue observed directly interfacing with the ceramic surface. Infrequently, small isolated areas showed cartilage formation with no noticeable endochondral ossification. At 4 weeks postimplantation of the ceramic with marrow cells, the osteogenesis in the ceramic accompanied an observed increase in compressive strength, rigidity, and energy absorption of the ceramic. These results suggest that a combination of porous ceramics and marrow cells may be useful for clinical problems requiring osseous reconstruction.
当未处理的多孔磷酸钙陶瓷被移植到皮下（s.c.）或肌肉内（i.m.）部位时，纤维血管组织在孔隙区域生长，没有骨形成的迹象。然而，当这些相同的陶瓷与同基因骨髓细胞结合时，在植入陶瓷的孔隙区域内观察到了骨生成。骨生成在植入后约3周时通过膜内骨形成过程在孔隙区域表面开始，新生骨组织直接与陶瓷表面相连。偶尔，小的孤立区域会出现软骨形成，但没有明显的软骨内成骨。在陶瓷与骨髓细胞植入后4周，陶瓷中的骨生成伴随着陶瓷抗压强度、刚度和能量吸收的增加。这些结果表明，多孔陶瓷和骨髓细胞的组合可能对需要骨重建的临床问题有用。
