Ting Chin-Tsung, Li Wan-Chun, Chen Chang-Yi, Tsai Tung-Hu
Division of Gastrointestinal Surgery, Department of Surgery, Taipei City Hospital (Renai Branch), Taipei, Taiwan, ROC; Institute of Traditional Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2015 Mar;78(3):139-44. doi: 10.1016/j.jcma.2014.09.003. Epub 2014 Oct 25.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. The clinical management of HCC remains a substantial challenge. Although surgical resection of tumor tissues seems promising, a high recurrence and/or metastasis rate accounting for disease-related death has led to an urgent need for improved postsurgical preventive/therapeutic clinical intervention. Developing advanced target-therapy agents such as sorafenib appears to be the only effective clinical intervention for patients with HCC to date, but only limited trials have been conducted in this regard. Because of their enhanced preventive/therapeutic effects, traditional Chinese herbal medicine (CHM)-derived compounds are considered suitable agents for HCC treatment. The CHM-derived compounds also possess multilevel, multitarget, and coordinated intervention effects, making them ideal candidates for inhibition of tumor progression and HCC metastasis. This article reviews the anticancer activity of various CHMs with the hope of providing a better understanding of how to best use CHM for HCC treatment.
肝细胞癌（HCC）是全球最常见的恶性肿瘤之一。HCC的临床管理仍然是一项重大挑战。尽管肿瘤组织的手术切除似乎很有前景，但高复发率和/或转移率导致与疾病相关的死亡，这使得迫切需要改进术后预防/治疗性临床干预措施。开发像索拉非尼这样的先进靶向治疗药物似乎是迄今为止对HCC患者唯一有效的临床干预措施，但在这方面仅进行了有限的试验。由于其增强的预防/治疗效果，源自传统中药（CHM）的化合物被认为是治疗HCC的合适药物。源自CHM的化合物还具有多层次、多靶点和协同干预作用，使其成为抑制肿瘤进展和HCC转移的理想候选药物。本文综述了各种CHM的抗癌活性，希望能更好地理解如何最好地将CHM用于HCC治疗。
