Zheng Yannan, Zhang Wenhui, Xu Lin, Zhou Hua, Yuan Man, Xu Hongxi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Engineering Research Center of Shanghai Colleges for Traditional Chinese Medicine (TCM) New Drug Discovery, Shanghai, China.
Front Oncol. 2022 Jan 26;11:795548. doi: 10.3389/fonc.2021.795548. eCollection 2021.
Liver cancer is the third most common cause of cancer-related death following lung and stomach cancers. As a highly lethal disease, liver cancer is diagnosed frequently in less developed countries. Natural compounds extracted from herbs, animals and natural materials have been adopted by traditional Chinese medicine (TCM) practices and reported to be effective in the development of new medications for the treatment of diseases. It is important to focus on the mechanisms of action of natural compounds against hepatocellular carcinoma (HCC), particularly in terms of cell cycle regulation, apoptosis induction, autophagy mediation and cell migration and invasion. In this review, we characterize novel representative natural compounds according to their pharmacologic effects based on recently published studies. The aim of this review is to summarize and explore novel therapeutic drug targets of natural compounds, which could accelerate the discovery of new anticancer drugs.
肝癌是继肺癌和胃癌之后癌症相关死亡的第三大常见原因。作为一种高致死性疾病，肝癌在欠发达国家经常被诊断出来。从草药、动物和天然材料中提取的天然化合物已被中医实践所采用，并据报道在开发治疗疾病的新药物方面有效。关注天然化合物对肝细胞癌（HCC）的作用机制非常重要，特别是在细胞周期调控、凋亡诱导、自噬介导以及细胞迁移和侵袭方面。在本综述中，我们根据最近发表的研究，根据其药理作用对新型代表性天然化合物进行了表征。本综述的目的是总结和探索天然化合物的新型治疗药物靶点，这可能会加速新抗癌药物的发现。
