Sandoval-Talamantes Ana Karen, Brito-Luna Myrian Johanna, Fafutis-Morris Mary, Villanueva-Quintero Delfina Guadalupe, Graciano-Machuca Omar, Ramírez-Dueñas María Guadalupe, Alvarado-Navarro Anabell
Centro de Investigación, Inmunología y Dermatología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México, Av. Federalismo Norte 3102, Atemajac del Valle, CP45190 Zapopan, Jalisco, Mexico.
Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Secretaria de Salud, Jalisco, México, Av. Federalismo Norte 3102, Atemajac del Valle, CP45190 Zapopan, Jalisco, Mexico.
Immunol Lett. 2015 Feb;163(2):221-6. doi: 10.1016/j.imlet.2014.10.004. Epub 2014 Oct 17.
Psoriasis is a chronic autoimmune inflammatory disease that affects the skin and the joints. Psoriasis is characterized by the keratinocyte proliferation, which is induced by cytokines Th1 and Th17. Patients with plaque psoriasis present a chronic inflammatory response with high levels of interleukin (IL)-12 and IL-23. Various single-nucleotide polymorphisms (SNP) have been identified in the IL12B gene, such as SNP 3' UTR 1188 A/C (SNP rs3212227), which has been associated with susceptibility to developing plaque psoriasis and with the production of IL-12 and IL-23 in individuals of different ethnic groups. In this study, we determined whether there is an association of SNP rs3212227 with the susceptibility of developing plaque psoriasis and with serum levels of IL-12 and IL-23 in Mestizo population in western Mexico. We included 112 patients with psoriasis and 112 clinical healthy individuals in the study. The frequencies of genotypes A/A, A/C, and C/C in patients with plaque psoriasis were 41, 53, and 6%, respectively, while in the control group, these were 37, 53, and 10%, respectively, without finding statistically significant differences between both groups (p>0.05). Although IL-12 and IL-23 serum levels were higher in patients than in controls, we found no significant differences. The group of patients with genotype CC presented the highest levels of IL-23 (p<0.05). These data suggest that the SNP rs3212227 phenotype is not associated with the risk of developing plaque psoriasis or with IL-12 and IL-23 levels in Mestizo population in western Mexico.
银屑病是一种影响皮肤和关节的慢性自身免疫性炎症性疾病。银屑病的特征是角质形成细胞增殖，这是由细胞因子Th1和Th17诱导的。斑块状银屑病患者呈现出高水平白细胞介素（IL）-12和IL-23的慢性炎症反应。在IL12B基因中已鉴定出各种单核苷酸多态性（SNP），例如SNP 3'UTR 1188 A/C（SNP rs3212227），其与斑块状银屑病的易感性以及不同种族个体中IL-12和IL-23的产生有关。在本研究中，我们确定了SNP rs3212227与墨西哥西部梅斯蒂索人群中斑块状银屑病的易感性以及IL-12和IL-23血清水平是否存在关联。我们纳入了112例银屑病患者和112名临床健康个体进行研究。斑块状银屑病患者中基因型A/A、A/C和C/C的频率分别为41%、53%和6%，而在对照组中，这些频率分别为37%、53%和10%，两组之间未发现统计学显著差异（p>0.05）。虽然患者的IL-12和IL-23血清水平高于对照组，但我们未发现显著差异。基因型CC的患者组呈现出最高水平的IL-23（p<0.05）。这些数据表明，SNP rs3212227表型与墨西哥西部梅斯蒂索人群中斑块状银屑病的发病风险或IL-12和IL-23水平无关。
