变应性鼻炎患儿中B细胞活化因子（BAFF）升高。
Elevated B cell-activating factor (BAFF) in children with allergic rhinitis.
作者信息
Liu Wenlong, Sun Changzhi, Luo Xi, Han Miaomiao, Zhou Lifeng, Li Jian, Wang Jie, Li Yan, Luo Renzhong, Li Huabin
机构信息
Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China.
Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China; Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2156-60. doi: 10.1016/j.ijporl.2014.09.031. Epub 2014 Oct 5.
OBJECTIVE
To evaluate the possible role of B cell-activating factor (BAFF) in children with allergic rhinitis (AR).
METHODS
Twenty-four AR children and 20 normal children were enrolled in this study and nasal lavage and serum were collected. The nasal and serum levels of BAFF were measured using enzyme-linked immunosorbent assay (ELISA). The relationship between serum BAFF and immunoglobulin A (IgA) was evaluated in AR children.
RESULTS
Our results showed that the nasal and serum levels of BAFF were significantly increased in AR children compared with controls (p<0.05). The nasal and serum levels of BAFF in AR children were significantly associated with disease severity (p<0.05). Moreover, the level of serum BAFF was negatively related to serum IgA level (p<0.05).
CONCLUSION
Our findings show BAFF expression was significantly increased and related to disease severity, indicating BAFF may be implicated in new treatment modalities for AR children.
目的
评估B细胞活化因子（BAFF）在变应性鼻炎（AR）患儿中的可能作用。
方法
本研究纳入24例AR患儿和20例正常儿童，采集鼻腔灌洗液和血清。采用酶联免疫吸附测定（ELISA）法检测鼻腔和血清中BAFF水平。评估AR患儿血清BAFF与免疫球蛋白A（IgA）之间的关系。
结果
我们的结果显示，与对照组相比，AR患儿鼻腔和血清中的BAFF水平显著升高（p<0.05）。AR患儿鼻腔和血清中的BAFF水平与疾病严重程度显著相关（p<0.05）。此外，血清BAFF水平与血清IgA水平呈负相关（p<0.05）。
结论
我们的研究结果表明BAFF表达显著增加且与疾病严重程度相关，提示BAFF可能参与AR患儿的新治疗模式。
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