Geisel Dominik, Lüdemann Lutz, Wagner Clemens, Stelter Lars, Grieser Christian, Malinowski Maciej, Stockmann Martin, Seehofer Daniel, Hamm Bernd, Gebauer Bernhard, Denecke Timm
Department of Diagnostic and Interventional Radiology, Charité, Campus Virchow-Klinikum, Berlin, Germany.
Acta Radiol. 2014 Mar;55(2):149-54. doi: 10.1177/0284185113495833. Epub 2013 Aug 1.
The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function.
用于肝功能测量的肝脏钆塞酸二钠摄取测量的最佳序列仍未确定。
前瞻性评估增加T1加权脂肪饱和三维序列的翻转角（FA）对右门静脉栓塞（PVE）后钆塞酸二钠磁共振成像（MRI）肝细胞摄取测量的影响。
对10例在扩大半肝切除术前接受PVE的患者，在PVE后14天使用标准FA为10°和增加FA为30°的肝脏钆塞酸二钠增强MRI进行检查。
右肝叶（RLL）在10°时相对强化为0.52±0.12，在30°时为1.41±0.39。左肝叶（LLL）在10°时相对强化为0.58±0.11，在30°时为2.05±0.61。RLL在30°时的相对强化显著高于10°（P = 0.009），LLL在30°序列中的相对强化也显著高于10°序列（P = 0.005）。
30°的翻转角增加了有和没有门静脉栓塞的肝叶之间的对比度。因此，摄取强度差异的敏感性增加。这对于更准确地确定区域肝功能差异以及进而估计未来残余肝功能可能具有价值。
