一名后皮质萎缩患者的tau蛋白、淀粉样蛋白及代谢减退情况
Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.
作者信息
Ossenkoppele Rik, Schonhaut Daniel R, Baker Suzanne L, O'Neil James P, Janabi Mustafa, Ghosh Pia M, Santos Miguel, Miller Zachary A, Bettcher Brianne M, Gorno-Tempini Maria L, Miller Bruce L, Jagust William J, Rabinovici Gil D
机构信息
Memory and Aging Center, University of California, San Francisco, San Francisco; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley.
出版信息
Ann Neurol. 2015 Feb;77(2):338-42. doi: 10.1002/ana.24321. Epub 2014 Dec 17.
Abstract
Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but until recently could only be assessed at autopsy. We report a patient with posterior cortical atrophy (visual variant of Alzheimer disease) who was studied using the novel tau tracer [(18) F]AV-1451 in conjunction with [(11) C]Pittsburgh compound B (PIB; amyloid) and [(18) F]fluorodeoxyglucose (FDG) positron emission tomography. Whereas [(11) C]PIB bound throughout association neocortex, [(18) F]AV-1451 was selectively retained in posterior brain regions that were affected clinically and showed markedly reduced [(18) F]FDG uptake. This provides preliminary in vivo evidence that tau is more closely linked to hypometabolism and symptomatology than amyloid.
摘要
确定淀粉样斑块和神经原纤维缠结对阿尔茨海默病脑功能障碍的相对贡献对于治疗方法至关重要，但直到最近，这只能在尸检时进行评估。我们报告了一名患有后皮质萎缩（阿尔茨海默病视觉变异型）的患者，该患者使用新型tau示踪剂[(18)F]AV - 1451结合[(11)C]匹兹堡化合物B（PIB；淀粉样蛋白）和[(18)F]氟脱氧葡萄糖（FDG）正电子发射断层扫描进行研究。[(11)C]PIB在整个联合新皮质中结合，而[(18)F]AV - 1451选择性地保留在临床上受影响且[(18)F]FDG摄取明显减少的后脑区域。这提供了初步的体内证据，表明tau比淀粉样蛋白与代谢减退和症状学的联系更紧密。
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