甲硫氨酸和胱氨酸双重剥夺应激通过诱导活性氧/自噬抑制胶质瘤增殖。
Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy.
作者信息
Liu Huailei, Zhang Weiguang, Wang Kaikai, Wang Xiaoxiong, Yin Fei, Li Chenguang, Wang Chunlei, Zhao Boxian, Zhong Chen, Zhang Jiakang, Peng Fei, Bi Yunke, Shen Chen, Hou Xu, Zhang Daming, Liu Yaohua, Ai Jing, Zhao Shiguang
机构信息
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, People's Republic of China; Institute of Brain Science, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, People's Republic of China; Institute of Brain Science, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
出版信息
Toxicol Lett. 2015 Jan 22;232(2):349-55. doi: 10.1016/j.toxlet.2014.11.011. Epub 2014 Nov 13.
Cancer cells are highly dependent on methionine and cystine (Met-Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met-Cys deprivation on glioma cells proliferation. The results showed that Met-Cys double deprivation had synergistic action on elevating ROS level, decreased GSH level and inhibition of glioma cell proliferation. Moreover, both of them deprivation triggered autophagy of glioma cells both in vitro and in vivo. Importantly, Met-Cys double restriction diet inhibited growth of glioma. These results provided a new regulation mechanism of Met-Cys metabolism on affecting glioma cell proliferation, suggesting that targeting Met-Cys metabolism may be a potential strategy for glioma therapy.
癌细胞的存活和增殖高度依赖于蛋氨酸和胱氨酸（Met-Cys）。然而，其分子机制尚不完全清楚。本研究旨在探讨Met-Cys剥夺对胶质瘤细胞增殖的影响。结果表明，Met-Cys双重剥夺在提高ROS水平、降低GSH水平以及抑制胶质瘤细胞增殖方面具有协同作用。此外，二者剥夺均在体外和体内引发了胶质瘤细胞的自噬。重要的是，Met-Cys双重限制饮食抑制了胶质瘤的生长。这些结果提供了一种Met-Cys代谢影响胶质瘤细胞增殖的新调控机制，表明靶向Met-Cys代谢可能是胶质瘤治疗的一种潜在策略。
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