Ma Chi, Xu Aoshuang, Zuo Liping, Li Qun, Fan Fengjuan, Hu Yu, Sun Chunyan
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Pharmaceuticals (Basel). 2025 Apr 28;18(5):640. doi: 10.3390/ph18050640.
Methionine, an essential amino acid, is obtained by dietary intake to fulfill the requirements of our bodies. Accumulating evidence indicates that methionine plays a pivotal role in various biological processes, including protein synthesis, energy metabolism, redox balance maintenance, and methylation modifications. Numerous advances underscore the heightened dependence of cancer cells on methionine, which is a significant factor in cancer pathogenesis and development. A profound comprehension of the intricate relationship between methionine metabolism and tumorigenesis is imperative for advancing the field of cancer therapeutics. Herein, we delve into the role of methionine in supporting cancer growth, the impact on epigenetic modifications, and the interaction between methionine and the tumor microenvironment. Additionally, we provide insights into the development of various methionine-targeted therapy strategies. This paper summarizes the current state of research and its translational potential, emphasizing the challenges and opportunities associated with harnessing methionine dependence as a target for innovative cancer treatments.
蛋氨酸是一种必需氨基酸，通过饮食摄入来满足我们身体的需求。越来越多的证据表明，蛋氨酸在各种生物过程中起着关键作用，包括蛋白质合成、能量代谢、维持氧化还原平衡以及甲基化修饰。众多进展突显了癌细胞对蛋氨酸的高度依赖性，这是癌症发病机制和发展的一个重要因素。深入理解蛋氨酸代谢与肿瘤发生之间的复杂关系对于推动癌症治疗领域的发展至关重要。在此，我们深入探讨蛋氨酸在支持癌症生长中的作用、对表观遗传修饰的影响以及蛋氨酸与肿瘤微环境之间的相互作用。此外，我们还提供了对各种针对蛋氨酸的治疗策略发展的见解。本文总结了当前的研究现状及其转化潜力，强调了将蛋氨酸依赖性作为创新癌症治疗靶点所面临的挑战和机遇。
