Qin Xiao-Ling, Zhang Qing-Shan, Sun Li, Hao Meng-Wei, Hu Zhao-Ting
Department of Neurology, Xuzhou Central Hospital, No. 199, South Jiefang Road, Xuzhou, Jiangsu, China.
Department of Clinical Laboratory, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Cell Biochem Biophys. 2015 May;72(1):49-56. doi: 10.1007/s12013-014-0402-x.
The objective of the study is to investigate the correlation between bilirubin and uric acid (UA) concentrations and symptoms of Parkinson's disease (PD) in Chinese population. A total of 425 PD patients and 460 controls were included in the current study. Patients were diagnosed by a neurologist and assessed using the Hoehn & Yahr (H&Y) scale. Venous blood samples were collected, and bilirubin and UA concentrations were analyzed. Compared to controls, indirect bilirubin (IBIL) and UA concentrations were lower in PD patients (P IBIL = 0.015, P UA = 0.000). Serum IBIL in different age subgroups and H&Y stage subgroups were also lower compared to the control group (P IBIL = 0.000, P UA = 0.000) but were not significantly different among these subgroups. Females in the control group had significantly lower serum IBIL and UA concentrations than males (P IBIL = 0.000, P UA = 0.000) and the PD group (P IBIL = 0.027, P UA = 0.000). In early PD (patients with <2-year medical history and no treatment), serum IBIL and UA concentrations were also lower than the controls (P IBIL = 0.013, P UA = 0.000). Although IBIL concentration was positively correlated with UA concentration in controls (R IBIL = 0.229, P IBIL = 0.004), this positive association was not observed in the PD group (R IBIL = -0.032, P IBIL = 0.724). Decreased levels of serum IBIL and UA were observed in PD patients. It is possible that individuals with decreased serum bilirubin and UA concentrations lack the endogenous defense system to prevent peroxynitrite and other free radicals from damaging and destroying dopaminergic cells in the substantia nigra. Our results provide a basis for further investigation into the role of bilirubin in PD.
本研究的目的是调查中国人群中胆红素和尿酸（UA）浓度与帕金森病（PD）症状之间的相关性。本研究共纳入425例PD患者和460例对照。患者由神经科医生诊断，并使用Hoehn & Yahr（H&Y）量表进行评估。采集静脉血样本，分析胆红素和UA浓度。与对照组相比，PD患者的间接胆红素（IBIL）和UA浓度较低（P IBIL = 0.015，P UA = 0.000）。不同年龄亚组和H&Y分期亚组的血清IBIL与对照组相比也较低（P IBIL = 0.000，P UA = 0.000），但这些亚组之间无显著差异。对照组女性的血清IBIL和UA浓度显著低于男性（P IBIL = 0.000，P UA = 0.000）以及PD组（P IBIL = 0.027，P UA = 0.000）。在早期PD（病史<2年且未接受治疗的患者）中，血清IBIL和UA浓度也低于对照组（P IBIL = 0.013，P UA = 0.000）。虽然对照组中IBIL浓度与UA浓度呈正相关（R IBIL = 0.229，P IBIL = 0.004），但在PD组中未观察到这种正相关（R IBIL = -0.032，P IBIL = 0.724）。PD患者血清IBIL和UA水平降低。血清胆红素和UA浓度降低的个体可能缺乏内源性防御系统来防止过氧亚硝酸盐和其他自由基对黑质中多巴胺能细胞的损伤和破坏。我们的结果为进一步研究胆红素在PD中的作用提供了依据。
