Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
General Medicine Department, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Neurodegener Dis. 2019;19(3-4):155-162. doi: 10.1159/000505852. Epub 2020 Feb 18.
We aimed to investigate the change of serum indirect bilirubin (IBIL) concentrations in patients with Parkinson's disease (PD) and whether IBIL concentrations were associated with the motor subtypes of PD.
A case-control study was performed to evaluate differences in bilirubin concentrations between 78 PD subjects and 78 controls. Venous blood samples were collected, and total bilirubin (TBIL), direct bilirubin (DBIL), and IBIL concentrations were analyzed between PD subjects and controls. PD patients were classified into three motor subtypes: tremor-dominant (TD), intermediate (I), and postural instability and gait disorder (PIGD). It was evaluated whether there were differences in IBIL concentrations between the different motor subtypes and between motor subtypes and controls.
PD patients had lower IBIL concentrations compared to controls (6.51 ± 4.03 vs. 10.82 ± 4.61, p< 0.001). There was no significant difference in IBIL concentrations between PD males and PD females (6.66 ± 3.64 vs. 6.22 ± 4.79, p =0.655). IBIL concentrations had negative relationships with levodopa-equivalent daily dose (LEDD) (R = -0.452, p < 0.001) and positive relationships with tremor score (R = 0.360, p = 0.001). IBIL concentrations were significantly lower for PIGD than for TD subtype (4.88 ± 4.03 vs. 9.00 ± 4.15, p< 0.001). The lower IBIL concentrations in PD compared to controls were mainly driven by the PIGD patients.
PD subjects showed lower levels of IBIL compared to controls. Higher IBIL levels were associated with TD motor subtype in PD, which could be related to the antioxidative properties of IBIL.
本研究旨在探讨帕金森病（PD）患者血清间接胆红素（IBIL）浓度的变化，以及 IBIL 浓度是否与 PD 的运动亚型有关。
采用病例对照研究评估 78 例 PD 患者和 78 例对照者胆红素浓度的差异。采集静脉血样，分析 PD 患者和对照者的总胆红素（TBIL）、直接胆红素（DBIL）和 IBIL 浓度。将 PD 患者分为震颤为主型（TD）、中间型（I）和姿势不稳及步态障碍型（PIGD）三个运动亚型。评估不同运动亚型之间以及运动亚型与对照组之间 IBIL 浓度是否存在差异。
PD 患者的 IBIL 浓度低于对照组（6.51 ± 4.03 vs. 10.82 ± 4.61，p<0.001）。PD 男性与 PD 女性的 IBIL 浓度无显著差异（6.66 ± 3.64 vs. 6.22 ± 4.79，p =0.655）。IBIL 浓度与左旋多巴等效日剂量（LEDD）呈负相关（R = -0.452，p < 0.001），与震颤评分呈正相关（R = 0.360，p = 0.001）。与 TD 亚型相比，PIGD 患者的 IBIL 浓度显著降低（4.88 ± 4.03 vs. 9.00 ± 4.15，p< 0.001）。与对照组相比，PD 患者 IBIL 浓度降低主要是由 PIGD 患者驱动的。
与对照组相比，PD 患者的 IBIL 水平较低。PD 中较高的 IBIL 水平与 TD 运动亚型相关，这可能与 IBIL 的抗氧化特性有关。
