Roukaerts Inge D M, Theuns Sebastiaan, Taffin Elien R L, Daminet Sylvie, Nauwynck Hans J
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Virus Res. 2015 Jan 22;196:30-6. doi: 10.1016/j.virusres.2014.10.023. Epub 2014 Nov 1.
Feline immunodeficiency virus (FIV) is a major pathogen in feline populations worldwide, with seroprevalences up to 26%. Virus strains circulating in domestic cats are subdivided into different phylogenetic clades (A-E), based on the genetic diversity of the V3-V4 region of the env gene. In this report, a phylogenetic analysis of the V3-V4 env region, and a variable region in the gag gene was made for 36 FIV strains isolated in Belgium and The Netherlands. All newly generated gag sequences clustered together with previously known clade A FIV viruses, confirming the dominance of clade A viruses in Northern Europe. The same was true for the obtained env sequences, with only one sample of an unknown env subtype. Overall, the genetic diversity of FIV strains sequenced in this report was low. This indicates a relatively recent introduction of FIV in Belgium and The Netherlands. However, the sample with an unknown env subtype indicates that new introductions of FIV from unknown origin do occur and this will likely increase genetic variability in time.
猫免疫缺陷病毒（FIV）是全球猫科动物群体中的一种主要病原体，血清阳性率高达26%。根据env基因V3 - V4区域的遗传多样性，家猫中传播的病毒株被细分为不同的系统发育分支（A - E）。在本报告中，对在比利时和荷兰分离出的36株FIV毒株的V3 - V4 env区域以及gag基因中的一个可变区域进行了系统发育分析。所有新生成的gag序列都与先前已知的A分支FIV病毒聚集在一起，证实了A分支病毒在北欧的主导地位。获得的env序列也是如此，只有一个样本属于未知的env亚型。总体而言，本报告中测序的FIV毒株的遗传多样性较低。这表明FIV在比利时和荷兰是相对近期才传入的。然而，具有未知env亚型的样本表明，确实会出现来源不明的FIV新传入情况，并且这可能会随着时间的推移增加遗传变异性。
