微胶囊释放的药理学方面——从聚合物多层膜到脂质膜
Pharmacological aspects of release from microcapsules - from polymeric multilayers to lipid membranes.
作者信息
Wuytens Pieter, Parakhonskiy Bogdan, Yashchenok Alexey, Winterhalter Mathias, Skirtach Andre
机构信息
Photonics Research Group, Department of Information Technology, Ghent University - imec, B-9000 Ghent, Belgium; Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
出版信息
Curr Opin Pharmacol. 2014 Oct;18:129-40. doi: 10.1016/j.coph.2014.09.016. Epub 2014 Oct 14.
This review is devoted to pharmacological applications of principles of release from capsules to overcome the membrane barrier. Many of these principles were developed in the context of polymeric multilayer capsule membrane modulation, but they are also pertinent to liposomes, polymersomes, capsosomes, particles, emulsion-based carriers and other carriers. We look at these methods from the physical, chemical or biological driving mechanisms point of view. In addition to applicability for carriers in drug delivery, these release methods are significant for another area directly related to pharmacology - modulation of the permeability of the membranes and thus promoting the action of drugs. Emerging technologies, including ionic current monitoring through a lipid membrane on a nanopore, are also highlighted.
本综述致力于胶囊释放原理在药理学中的应用，以克服膜屏障。其中许多原理是在聚合物多层胶囊膜调节的背景下发展起来的，但它们也适用于脂质体、聚合物囊泡、胶囊体、颗粒、乳液基载体和其他载体。我们从物理、化学或生物驱动机制的角度审视这些方法。除了适用于药物递送中的载体外，这些释放方法对于与药理学直接相关的另一个领域——调节膜的通透性从而促进药物作用也具有重要意义。还重点介绍了新兴技术，包括通过纳米孔上的脂质膜监测离子电流。
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