Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Chem Soc Rev. 2012 Apr 7;41(7):2867-84. doi: 10.1039/c2cs15296g. Epub 2012 Jan 26.
The advent of Layer-by-Layer (LbL) assembly to fabricate polymeric as well as hybrid multilayer thin films has opened exciting avenues for the design of multifunctional drug carriers with extreme control over their physico-chemical properties. These polymeric multilayer capsules (PMLC) are typically fabricated by sequential adsorption of polymers onto a spherical substrate with dimensions varying from 10 nm to several microns and larger. In this critical review, we give an overview of the recent advances in the field of PMLC with respect to drug delivery and point out how sophisticated capsule engineering can lead to well-defined drug carriers with unique properties (139 references).
层层（LbL）组装技术的出现为制造聚合物和杂化多层薄膜开辟了令人兴奋的途径，使人们能够对其物理化学性质进行极端控制，从而设计多功能药物载体。这些聚合物多层胶囊（PMLC）通常通过将聚合物顺序吸附到尺寸从 10nm 到几微米甚至更大的球形基底上来制备。在这篇评论中，我们概述了 PMLC 在药物传递方面的最新进展，并指出复杂的胶囊工程如何能够导致具有独特性质的明确定义的药物载体（139 篇参考文献）。
