介质研磨对壳聚糖降血脂和抗氧化活性的影响。
Effect of media milling on lipid-lowering and antioxidant activities of chitosan.
作者信息
Zhang Wei, Xia Wenshui
机构信息
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei, PR China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, PR China.
出版信息
Int J Biol Macromol. 2015 Jan;72:1402-5. doi: 10.1016/j.ijbiomac.2014.10.049. Epub 2014 Oct 27.
The effect of media milling on lipid-lowering and antioxidant activities of chitosan was studied in rats fed high-fat diets. Results showed that media-milled chitosan was more effective than chitosan in reducing body weight gain and liver fat accumulation of rats. Compared with chitosan, the reducing effects of media-milled chitosan on serum triacylglycerol (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were increased by 10.1, 7.5 and 10.2%, and liver TG and TC-reducing effects were increased by 16.2 and 14.6%, respectively. Rats fed media-milled chitosan showed decreased levels of free fatty acid (FFA) and thiobarbituric acid-reactive substances (TBARS) and increased superoxide dismutase (SOD) activity. The cholesterol and fat in feces of rats fed media-milled chitosan were higher than those of rats fed chitosan. These results suggested media milling enhanced the lipid-lowering and antioxidant activities of chitosan, and the reason might be partly due to its effect on strengthening the ability of chitosan in promoting fecal lipid excretions.
在高脂饮食喂养的大鼠中研究了介质研磨对壳聚糖降血脂和抗氧化活性的影响。结果表明，介质研磨壳聚糖在降低大鼠体重增加和肝脏脂肪积累方面比壳聚糖更有效。与壳聚糖相比，介质研磨壳聚糖对血清三酰甘油（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的降低作用分别提高了10.1%、7.5%和10.2%，对肝脏TG和TC的降低作用分别提高了16.2%和14.6%。喂食介质研磨壳聚糖的大鼠游离脂肪酸（FFA）和硫代巴比妥酸反应性物质（TBARS）水平降低，超氧化物歧化酶（SOD）活性增加。喂食介质研磨壳聚糖的大鼠粪便中的胆固醇和脂肪高于喂食壳聚糖的大鼠。这些结果表明介质研磨增强了壳聚糖的降血脂和抗氧化活性，其原因可能部分是由于其对增强壳聚糖促进粪便脂质排泄能力的作用。
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