Hu Qiang, Zhang Sheng-Yu, Liu Fei, Zhang Xiao Jie, Cui Guang-Cheng, Yu En-Qing, Xu Xian-Feng, Li Ping, Xiao Jian-Qi, Wei Dong-Mei, Zang Yin-Yin
Department of Psychology, Qiqihar Mental Health Center, Linhua Road No. 6, Jianhua District, Qiqihar 161000, China.
Institute of Forensic Science, Ministry of Justice, P.R. China, Guangfu Road No. 1347, Shanghai 200030, China.
J Affect Disord. 2015 Feb 1;172:103-9. doi: 10.1016/j.jad.2014.09.039. Epub 2014 Oct 2.
We performed the present meta-analysis in order to evaluate the influence of a common polymorphism (C825T, rs5443 C>T) in the GNB3 gene on the efficacy of antidepressants in the treatment of major depressive disorder (MDD).
A relevant literature was searched using the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CBM and CNKI databases without any language restrictions. STATA Version 12.0 software (Stata Corporation, College Station, Texas USA) was used for this meta-analysis. Odds ratio (OR) and its corresponding 95% confidence interval (95% CI) were calculated.
Our findings suggested that the GNB3 C825T polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients under the allele and dominant models. Furthermore, we found significant associations between GNB3 C825T polymorphisms and antidepressant-induced remission in MDD patients. Ethnicity-stratified analysis indicated that GNB3 C825T polymorphisms may be strongly related to the efficacy of antidepressants in the treatment of MDD among Asians, but not in Caucasians (all P>0.05).
Our findings provide empirical evidence that GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients.
我们进行了本次荟萃分析，以评估GNB3基因中一种常见多态性（C825T，rs5443 C>T）对抑郁症（MDD）患者抗抑郁药疗效的影响。
使用PubMed、Embase、Web of Science、Cochrane图书馆、CISCOM、CINAHL、谷歌学术、中国生物医学文献数据库和中国知网数据库检索相关文献，无任何语言限制。本荟萃分析使用STATA 12.0软件（美国德克萨斯州大学城Stata公司）。计算优势比（OR）及其相应的95%置信区间（95%CI）。
我们的研究结果表明，在等位基因和显性模型下，GNB3 C825T多态性与MDD患者对抗抑郁药的较高反应率显著相关。此外，我们发现GNB3 C825T多态性与MDD患者抗抑郁药诱导的缓解之间存在显著关联。种族分层分析表明，GNB3 C825T多态性可能与亚洲人MDD患者抗抑郁药的疗效密切相关，但与白种人无关（所有P>0.05）。
我们的研究结果提供了实证证据，表明GNB3 C825T多态性可能与抗抑郁药治疗MDD的疗效相关，尤其是在亚洲患者中。
