Zubrikhina G N, Ermilova V D, Kuz'mina Z V, Bassalyk L S
Arkh Patol. 1989;51(3):10-6.
The receptor status of the tumors examined in 74 patients with breast cancer was found to correlate with its ploidy and proliferative activity as evidenced by flow cytometry and it failed to correlate with a histological tumor type and metastatic involvement of regional lymph nodes. In terms of DNA content, the receptor-positive tumors were more frequently diploid, the receptor-negative ones were aneuploid. The proliferation index (PI) for the receptor-negative tumors was significantly higher than that for the receptor-positive ones. The diploid tumors showed lower proliferative activity than the aneuploid ones. Among the aneuploid tumors, PI for infiltrative lobular cancer was significantly lower than that for infiltrative duct cancer. Early in invasion, duct carcinoma was predominantly diploid, of grade I-IIA malignancy and more infrequently metastasized into regional lymph nodes. Grade IIB-III malignant tumors were chiefly aneuploid and more frequently metastasized into regional lymph nodes.
通过流式细胞术发现，74例乳腺癌患者所检测肿瘤的受体状态与其倍性和增殖活性相关，而与肿瘤组织学类型及区域淋巴结转移情况无关。就DNA含量而言，受体阳性肿瘤多为二倍体，受体阴性肿瘤多为非整倍体。受体阴性肿瘤的增殖指数（PI）显著高于受体阳性肿瘤。二倍体肿瘤的增殖活性低于非整倍体肿瘤。在非整倍体肿瘤中，浸润性小叶癌的PI显著低于浸润性导管癌。在侵袭早期，导管癌多为二倍体，恶性程度为I-IIA 级，较少转移至区域淋巴结。IIB-III级恶性肿瘤主要为非整倍体，更易转移至区域淋巴结。
