Alsofyani Khouloud A
Department of Pediatric, Section of Pediatric Critical Care, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Jun;39(6):622-626. doi: 10.15537/smj.2018.6.22025.
Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life threatening levels. Hypercalcemia is a significant reason of subcutaneous fat necrosis and needs an intervention involving hyperhydration, calcitonin, diuretics, steroids and sometimes bisphosphonate in resistant cases. Here, we have reported the case of a term infant who developed extensive subcutaneous fat necrosis in the first week of life after significant perinatal hypoxic injury. Her condition was complicated by hypercalcemia resistant to prolonged medical treatment with hyperhydration, diuretic and steroid but eventually the infant responded to high doses of calcitonin.
新生儿皮下脂肪坏死是一种非感染性脂膜炎。它是一种不常见的病症，主要发生在足月出生且出生时患有如缺氧缺血性脑病等严重疾病的婴儿出生后的头几周内。新生儿皮下脂肪坏死通常是一种自限性疾病，但可能与高钙血症有关，高钙血症可能会导致危及生命的水平。高钙血症是新生儿皮下脂肪坏死的一个重要原因，需要采取包括补液、降钙素、利尿剂、类固醇，在耐药病例中有时还需要使用双膦酸盐的干预措施。在此，我们报告了一例足月婴儿的病例，该婴儿在经历严重围产期缺氧损伤后，于出生后第一周出现广泛的皮下脂肪坏死。她的病情因对补液、利尿剂和类固醇的长期治疗有抵抗性的高钙血症而复杂化，但最终该婴儿对高剂量降钙素产生了反应。
