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在尼日利亚乔斯治疗喉癌的挑战。

The challenges of treating laryngeal carcinoma in jos, Nigeria.

作者信息

Adoga As, Ma'an En

机构信息

Department of ENT Surgery, Jos University Teaching Hospital, Jos, Nigeria.

出版信息

J West Afr Coll Surg. 2011 Apr;1(2):63-75.

Abstract

BACKGROUND

Laryngeal cancers are not uncommon with several factors affecting its management in our environment compared to the developed countries. Such factors include the time of presentation and diagnosis, co-morbid disease, finance, consent, treatment options, surgical expertise and the problems of follow up. Thus this results to a lot management challenges to both the patients and the care givers.

AIM

The aim of this paper is to highlight the challenges encountered in the management of laryngeal cancers at the Jos University Teaching Hospital, Nigeria.

DESIGN OF STUDY

it is a retrospective study.

SETTING

The study was carried out at the ENT department of the Jos University Teaching Hospital and Bingham (ECWA Evangel) Hospital Jos Nigeria.

METHOD

This was a 48-month (October 2005 - September 2009) review of laryngeal cancers seen and treated in these hospitals. Data extracted included age, gender, histologic diagnosis and treatment modality. Data was analyzed using simple descriptive method and the result presented in tabular forms.

RESULT

A total of twenty one (21) cases consisting of 20 males and a female were seen during the period. The age range was 30 years to 70 years. The average age was 56.14 years. The time of presentation ranged from 3 months (earliest) to 2years. Twenty cases (95.24%) were advanced diseases with only one early disease. The histological types were 6 each for well and moderately differentiated squamus cell carcinoma respectively, 2 each for poorly differentiated and squamus cell carcinoma (uncharacterized) and 1 carcinoma insitu. Two patients (a male and female) were seropositive for HIV type I. Twenty (95.24%) of the patients had tracheostomy at presentation with two having peristomal spread in the course of the disease. Eight (38.10%) patients had total laryngectomy out of which one was a salvage laryngectomy with subsequent right pectoralis major myocutaneous flap; 6 had concomitant chemoradiotherapy with one discontinuing after the first course and while the sixth total laryngectomee had no chemoradiotherapy. Three (14.29%) had primary radiotherapy; 2 of the cases were advanced diseases and one early disease. Eight (38.10%) had no treatment. Of the 6 laryngectomees, three had tracheo-oesophageal fistula post-operatively while one had disease recurrence and died. The first laryngectomy case is still on follow-up, disease free four years now while the rest have been lost to follow up.

CONCLUSION

Education and provision of standard oncologic treatment centres with trained personnel will help in alleviating theses challenges by providing treatment, data for assessment and improving the standard of our treatment.

摘要

背景

与发达国家相比,喉癌在我们所处环境中并不罕见,有多种因素影响其治疗。这些因素包括就诊和诊断时间、合并疾病、资金、同意情况、治疗选择、手术专业知识以及随访问题。因此,这给患者和护理人员带来了诸多管理挑战。

目的

本文旨在突出尼日利亚乔斯大学教学医院在喉癌管理中遇到的挑战。

研究设计

这是一项回顾性研究。

研究地点

该研究在尼日利亚乔斯的乔斯大学教学医院耳鼻喉科和宾厄姆(伊夸福音派教会)医院开展。

方法

这是对这些医院在48个月(2005年10月至2009年9月)期间诊治的喉癌病例的回顾。提取的数据包括年龄、性别、组织学诊断和治疗方式。数据采用简单描述性方法进行分析,结果以表格形式呈现。

结果

在此期间共诊治了21例病例,其中男性20例,女性1例。年龄范围为30岁至70岁,平均年龄为56.14岁。就诊时间从3个月(最早)至2年不等。20例(95.24%)为晚期疾病,仅1例为早期疾病。组织学类型中,高分化和中分化鳞状细胞癌各6例,低分化和未分化鳞状细胞癌各2例,原位癌1例。2例患者(1男1女)HIV - I型血清学检测呈阳性。20例(95.24%)患者就诊时行气管切开术,其中2例在病程中出现造口周围扩散。8例(38.10%)患者行全喉切除术,其中1例为挽救性全喉切除术,随后行右胸大肌肌皮瓣修复;6例接受同步放化疗,其中1例在第一疗程后中断治疗,而第6例全喉切除患者未接受放化疗。3例(14.29%)接受单纯放疗;其中2例为晚期疾病,1例为早期疾病。8例(38.10%)未接受治疗。在6例全喉切除患者中,3例术后发生气管食管瘘,1例疾病复发死亡。第一例全喉切除患者仍在随访中,目前已无病生存4年,其余患者失访。

结论

开展教育并提供配备训练有素人员的标准肿瘤治疗中心,将有助于通过提供治疗、评估数据和提高我们的治疗水平来缓解这些挑战。

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