Fasunla Ayotunde James, Ogundoyin Oluwole Agboola, Onakoya Paul Adekunle, Nwaorgu Onyekwere George
Department of Otorhinolaryngology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
Niger Med J. 2016 Sep-Oct;57(5):280-285. doi: 10.4103/0300-1652.190596.
Malignant laryngeal tumors are uncommon. Late presentation of the disease may worsen management outcomes. We described the epidemiologic, clinicopathologic profile, and management outcomes of laryngeal tumors in a tertiary health institution in Nigeria.
An 11-year retrospective review of medical records of patients managed for malignant laryngeal tumor at the University College Hospital, Ibadan, Nigeria, was performed.
There were 97 patients comprising 74 (76.3%) males and 23 (23.7%) females with a mean age of 60.48 ± 12.15 years. The mean duration of illness was 7.3 ± 3.8 months. History of cigarette smoking and alcohol consumption was in 2.1% and 14.4% patients, respectively. The most common clinical presentations were hoarseness, cough, and dyspnea. Transglottis (91.8%) was the most common anatomic tumor location and 92.8% patients presented in advanced disease stage. Four histologic types were identified with squamous cell carcinoma accounting for 96.9%. About 92% patients had emergency tracheostomy and 56 (57.7%) patients had total laryngectomy. The postoperative complications were pharyngocutaneous fistula (5.2%) and peristomal recurrence (3.1%). The 5-year survival rate was 52.5%.
Malignant laryngeal tumors are uncommon, but more females are getting the disease. Squamous cell carcinoma is the most common histologic variant. Late stage disease presentation and initial wrong diagnosis contributed to the poor management outcome.
恶性喉肿瘤并不常见。疾病的晚期表现可能会使治疗结果恶化。我们描述了尼日利亚一家三级医疗机构中喉肿瘤的流行病学、临床病理特征及治疗结果。
对尼日利亚伊巴丹大学学院医院收治的恶性喉肿瘤患者的病历进行了11年的回顾性研究。
97例患者中，男性74例（76.3%），女性23例（23.7%），平均年龄60.48±12.15岁。平均病程为7.3±3.8个月。分别有2.1%和14.4%的患者有吸烟和饮酒史。最常见的临床表现为声音嘶哑、咳嗽和呼吸困难。跨声门型（91.8%）是最常见的肿瘤解剖位置，92.8%的患者在疾病晚期就诊。共识别出四种组织学类型，其中鳞状细胞癌占96.9%。约92%的患者接受了紧急气管切开术，56例（57.7%）患者接受了全喉切除术。术后并发症为咽皮肤瘘（5.2%）和造口周围复发（3.1%）。5年生存率为52.5%。
恶性喉肿瘤并不常见，但患此病的女性增多。鳞状细胞癌是最常见的组织学变异类型。疾病晚期就诊和最初的误诊导致了较差的治疗结果。
