使用壳聚糖合成YF3:Yb,Er上转换纳米荧光团及其在MCF-7细胞中的细胞毒性。
Synthesis of YF3: Yb, Er upconverting nanofluorophores using chitosan and their cytotoxicity in MCF-7 cells.
作者信息
Gayathri Sethuraman, Ghosh Oriparambil Sivaraman Nirmal, Viswanath Annamraju Kasi, Sudhakara P, Reddy M Jeevan Kumar, Shanmugharaj A M
机构信息
Nanophotonics and Nanoelectronics Research Laboratory, Centre for Nanoscience and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, Puducherry - 605014, India.
Nanophotonics and Nanoelectronics Research Laboratory, Centre for Nanoscience and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, Puducherry - 605014, India.
出版信息
Int J Biol Macromol. 2015 Jan;72:1308-12. doi: 10.1016/j.ijbiomac.2014.10.019. Epub 2014 Oct 23.
In this work, we described one pot hydrothermal synthesis of surface modified water soluble YF3: Yb, Er upconverting nanofluorophores (UCNFs) using natural biopolymer chitosan. The obtained nanocrystals have undergone X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), high resolution transmission electron microscopy (HRTEM) and photoluminescence (PL) studies. The nanoparticles possess uniform particle size distribution with average size about 27 nm. The cytotoxicity results revealed that the chitosan capped nanoparticles exhibit excellent biocompatibility in human breast cancer cells. In conclusion, the water soluble chitosan capped YF3: Yb, Er nanoparticles could be used as a potential candidate in bio-imaging and therapeutic applications.
在这项工作中，我们描述了使用天然生物聚合物壳聚糖通过一锅水热法合成表面改性的水溶性YF3:Yb,Er上转换纳米荧光体（UCNFs）。所获得的纳米晶体经过了X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、能量色散光谱（EDS）、高分辨率透射电子显微镜（HRTEM）和光致发光（PL）研究。这些纳米颗粒具有均匀的粒径分布，平均粒径约为27纳米。细胞毒性结果表明，壳聚糖包覆的纳米颗粒在人乳腺癌细胞中表现出优异的生物相容性。总之，水溶性壳聚糖包覆的YF3:Yb,Er纳米颗粒可作为生物成像和治疗应用的潜在候选物。
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