Parcerisa X, Cases A, Botey A, Gaya J, Ingelmo M, Revert L, Rivera F
Internal Medicine, Department Hospital Clínic i Provincial. Barcelona. Spain.
Clin Exp Hypertens A. 1989;11 Suppl 1:303-9. doi: 10.3109/10641968909045435.
In order to study the density and response to dynamic exercise of lymphocyte beta 2-adrenoceptors in essential hypertension, 30 moderate essential hypertensives (12 men: 18 women, mean age 50.3 +/- 9.2 years) and 14 normotensive controls (8 men: 7 women, mean age 47 +/- 15 years) were studied. Beta 2-adrenoceptors density in basal conditions was higher in essential hypertensives than in controls (1950 +/- 625 vs 1278 +/- 356 binding sites per cell [bs/c], respectively, p less than 0.01) (mean +/- SD). After dynamic exercise beta 2-adrenoceptors density increased both in controls (to 1491 +/- 342 bs/c, p less than 0.01) and in hypertensives (to 2632 +/- 715 bs/c, p less than 0.001). However, the percentage of increase after the exercise was significantly higher in hypertensives than in controls (40.5 +/- 6.1 vs 20.2 +/- 6.5%, p less than 0.05). In summary, the higher density in basal conditions, as well as the exaggerated increase in the number of beta 2-adrenoceptors after dynamic exercise observed in essential hypertension, suggest an impaired regulation of these receptors in essential hypertension.
为研究原发性高血压患者淋巴细胞β2 - 肾上腺素能受体的密度及其对动态运动的反应，我们对30例中度原发性高血压患者（12例男性，18例女性，平均年龄50.3±9.2岁）和14例血压正常的对照者（8例男性，7例女性，平均年龄47±15岁）进行了研究。在基础状态下，原发性高血压患者的β2 - 肾上腺素能受体密度高于对照组（分别为1950±625和1278±356个结合位点/细胞[bs/c]，p<0.01）（均值±标准差）。动态运动后，对照组（升至1491±342 bs/c，p<0.01）和高血压患者（升至2632±715 bs/c，p<0.001）的β2 - 肾上腺素能受体密度均增加。然而，运动后高血压患者的增加百分比显著高于对照组（40.5±6.1对20.2±6.5%，p<0.05）。总之，原发性高血压患者基础状态下较高的受体密度以及动态运动后β2 - 肾上腺素能受体数量的过度增加，提示原发性高血压中这些受体的调节受损。
