Doyle V, O'Malley K, Kelly J G
J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):738-40. doi: 10.1097/00005344-198209000-00007.
beta-Adrenoceptor density was measured in lymphocytes from neonates and from normotensive and hypertensive adults aged from 18 to 85 years. Receptor density did not differ in young and elderly people. In normotensive but not in hypertensive people there was a peak in beta-adrenoceptor density in middle life; otherwise, receptor densities were similar in normotensive and hypertensives. Neonates had a lower lymphocyte receptor density than adults. Decreases in beta-adrenoceptor-mediated responses in old age may be due to alterations in postreceptor events.
测定了新生儿以及18至85岁血压正常和高血压成年人淋巴细胞中的β-肾上腺素能受体密度。年轻人和老年人的受体密度没有差异。在血压正常的人群中，中年人的β-肾上腺素能受体密度有一个峰值，而高血压人群中则没有；除此之外，血压正常者和高血压患者的受体密度相似。新生儿的淋巴细胞受体密度低于成年人。老年时β-肾上腺素能受体介导反应的降低可能是由于受体后事件的改变所致。
