长期给予锂对大鼠纹状体多巴胺代谢的影响。
The effect of chronic lithium administration on dopamine metabolism in rat striatum.
作者信息
Hesketh J E, Nicolaou N M, Arbuthnott G W, Wright A K
出版信息
Psychopharmacology (Berl). 1978 Mar 1;56(2):163-6. doi: 10.1007/BF00431843.
PMID:25454
Abstract
Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylase activity after 1, 2, and 3 weeks treatment. The results indicate an increase in the release and turnover of dopamine in the lithium-treated animals.
摘要
对食用含氯化锂饲料的大鼠的纹状体多巴胺及其代谢产物进行了研究。结果显示，给予锂盐3周后，高香草酸和3,4 - 二羟基苯乙酸水平升高，但多巴胺浓度无显著变化。在1周、2周和3周的治疗后，酪氨酸羟化酶活性没有变化。结果表明，锂处理动物体内多巴胺的释放和周转增加。
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